Tensile Expansion Mass Spectrometry for single cell metabolomics imaging
Jason A. Guerrero, Ethan A. Older, Marouen Zammali, Vignesh Venkataramani, Ramita Arampongpun, Danielle R. Latham, Dalia Riad, Jan Schwenzfeier, Alexander Potthoff, Diandra M. Vaval Taylor, Joanna E. Burdette, Roberto C. Andresen Eguiluz, Jens Soltwisch, Lydia Kisley, Laura M. Sanchez
Tensile stretching of live, unfixed OVCAR8 cells on a fibronectin-functionalized double-network hydrogel expands them about 1.7x linearly, enabling single-cell MALDI metabolite imaging on unmodified commercial instruments.
bioRxiv · Aug 20, 2026 · PreprintBiochemistry✦ In-depth digest