Author

Alexander Potthoff

University of MünsterORCID 0000-0002-5452-7700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:imputation· 1

Frequent Co-Authors

Jens SoltwischiD· 3 shared Jan SchwenzfeieriD· 2 shared Klaus DreisewerdiD· 2 shared Oliver SoehnleiniD· 2 shared Sebastian BessleriD· 2 shared Angelo Novak· 1 shared Anika GrüneboomiD· 1 shared Antonia GockeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

Jens SoltwischORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 20, 2026

✦ In-depth digest

Tensile Expansion Mass Spectrometry for single cell metabolomics imaging

Jason A. Guerrero, Ethan A. Older, Marouen Zammali…·Laura M. Sanchez

Tensile stretching of live, unfixed OVCAR8 cells on a fibronectin-functionalized double-network hydrogel expands them about 1.7x linearly, enabling single-cell MALDI metabolite imaging on unmodified commercial instruments.

1 citation

humanmetabolomics

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ImmunologybioRxivPreprintNov 25, 2025

TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming

Lars Widera, Philippa Spangenberg, Devon Siemes…·Daniel Robert Engel

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

DOI 10.1101/2025.11.25.688397

humanproteomics

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Cell BiologyNature CommunicationsPeer-reviewedOct 15, 2025

Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy

Alexander Potthoff, Jan Schwenzfeier, Marcel Niehaus…·Jens Soltwisch

This paper integrates MALDI-MSI with bright-field and fluorescence microscopy to correlate lipid profiles with morphological and protein features at the single-cell level.

46 citationstop 1%

mouseimaging

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