Lydia Kisley

The Tensile Expansion Microscopy (TExM) cell stretcher: an iris expansion device integrated with automated real-time autofocus and tracking to super-resolve cells

The paper introduces a TExM cell stretcher that applies isotropic equibiaxial force to achieve 1664% aerial strain for super-resolution imaging, with automated autofocus and tracking.

Tensile Expansion Mass Spectrometry for single cell metabolomics imaging

Tensile stretching of live, unfixed OVCAR8 cells on a fibronectin-functionalized double-network hydrogel expands them about 1.7x linearly, enabling single-cell MALDI metabolite imaging on unmodified commercial instruments.

Tensile Expansion Microscopy Applies Mechanical Force to Super-resolve Fixed and Image Live Cellular Samples

This paper introduces TExM, a method to super-resolve fixed and live cellular samples by mechanically expanding hydrogels during continuous imaging.

Chemical interactions in polyethylene glycol-induced condensates lead to an anomalous FRET response from a flexible linker-fluorescent protein crowding sensor

This study investigates how PEG-induced phase separation affects FRET-based crowding sensors, showing that CrH2 forms puncta while CrD does not, and identifies biophysical mechanisms behind the sensor response.

Cross-correlation increases sampling in diffusion-based super-resolution optical fluctuation imaging

This paper demonstrates that cross-correlation improves sampling and reduces aliasing in diffusion-based super-resolution optical fluctuation imaging for nanoscale dynamics and structure analysis.