Jens Soltwisch

Tensile Expansion Mass Spectrometry for single cell metabolomics imaging

Tensile stretching of live, unfixed OVCAR8 cells on a fibronectin-functionalized double-network hydrogel expands them about 1.7x linearly, enabling single-cell MALDI metabolite imaging on unmodified commercial instruments.

Cannibalism Shapes Biofilm Structure and Composition in Bacillus subtilis

This paper investigates how cannibalism in Bacillus subtilis biofilms affects structure and composition by analyzing toxin production and spatial distribution.

Vascular Basement Membrane Laminins Modulate Functional Zonation of Cerebral Microvessels

This study shows that vascular basement membrane laminins regulate cerebral microvessel functional zonation by modulating endothelial and mural cell identity and vascular permeability.

TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

Subcellular mass spectrometry imaging of lipids and nucleotides using transmission geometry ambient laser desorption and plasma ionisation

This paper introduces a subcellular mass spectrometry imaging technique that enhances lipid and nucleotide detection using transmission geometry ambient laser desorption and plasma ionisation.

LipidQMap - An Open-Source Tool for Quantitative Mass Spectrometry Imaging of Lipids

LipidQMap is an open-source tool for processing quantitative mass spectrometry imaging lipidomics data, enabling accurate and reproducible spatial lipid quantification across MSI platforms.

Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy

This paper integrates MALDI-MSI with bright-field and fluorescence microscopy to correlate lipid profiles with morphological and protein features at the single-cell level.

Single-cell mass spectrometry imaging combined with immunofluorescence reveals neutrophil heterogeneity in inflammation

The paper combines single-cell mass spectrometry imaging and immunofluorescence to identify pathogenic neutrophils in liver cirrhosis patients.

msiFlow: Automated Workflows for Reproducible and Scalable Multimodal Mass Spectrometry Imaging and Immunofluorescence Microscopy Data Processing and Analysis

msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.

Large-Scale Evaluation of Spatial Metabolomics Protocols and Technologies

The paper evaluates spatial metabolomics protocols and technologies, showing extensive metabolite coverage and comparable results across imaging MS methods.