Advancements in Transdermal Drug Delivery

A piezoelectric electroporator (Piezopen) for enhanced ''naked'' RNA vaccine delivery

The paper introduces Piezopen, a low-cost electroporator that delivers naked RNA vaccines effectively, achieving comparable immunogenicity to LNPs without systemic inflammation.

Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy

This paper develops PPPd-MNs that use PEI's cytotoxicity and Pd catalysis to synergistically treat melanoma, achieving 98% tumor inhibition in mice.

Disc-Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery

This paper develops disc-toroid hybrid lipid nanoparticles for efficient drug delivery, showing high encapsulation efficiency and biocompatibility for subcutaneous administration.

Evaluation of Antigen Expression and Early Immune Response following Cutaneous Suction-mediated DNA Delivery

This study evaluates antigen expression and early immune response in rat skin after suction-mediated DNA delivery using immunofluorescence staining.

Enhanced cellular and transdermal delivery of the modified chromatin using gH625 cell-penetrating peptide

This study demonstrates that gH625-modified chromatin enhances transdermal delivery of EGF, showing comparable biological activity to free EGF in cells.

A Microneedle Device for Rapid Dermal Interstitial Fluid Sampling

This paper introduces a microneedle device that rapidly collects dermal interstitial fluid with high efficiency and low failure rate, improving ISF sampling for diagnostics.

Free-Form Microfluidic Microneedle Array Patches

This paper develops microfluidic microneedle array patches using biomimetic design and 3D printing to overcome payload and scalability challenges in transdermal drug delivery.

Formulation, Characterization, and in vivo Immunogenicity of Heat-Stabilized Dissolvable Microneedles Containing a Novel VLP Vaccine

This study develops heat-stabilized dissolvable microneedles containing a novel VLP vaccine, showing robust immunogenicity and stability under extreme storage conditions.

Transcutaneous delivery of disease specific PI3K/Akt/mTOR inhibitor based hybrid nanoparticles in hydrogel system for the management of psoriasis: Insights from in vivo studies

This paper develops a hybrid nanoparticle-hydrogel system for psoriasis treatment, showing improved drug delivery and reduced PASI scores in vivo.

Skin hydration by natural moisturizing factors, a story of H-bond networking

This study investigates the role of natural moisturizing factors in skin hydration through molecular dynamics simulations, showing their impact on lipid diffusion and membrane properties.

Eugenol loaded lipid nanoparticles derived hydrogels ameliorate psoriasis-like skin lesions by lowering oxidative stress and modulating inflammation

This paper develops eugenol-loaded lipid nanoparticles in hydrogels to treat psoriasis by reducing oxidative stress and inflammation, showing significant improvement in psoriasis symptoms.

Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi

This study develops UCL-211, a transdermal delivery system for miR211-5p, which stabilizes BRAFV600E+ melanocytic nevi by maintaining them in a growth-arrested state.

Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models

This study uses electrical impedance spectroscopy to non-invasively measure barrier function in 3D human epidermal equivalents over time, identifying frequency ranges linked to keratinocyte differentiation and stratum corneum thickness.

In silico validation and fabrication of matrix diffusion based polymeric transdermal films for repurposing gabapentin hydrochloride in oncogenic neuropathic pain.

The paper validates and fabricates transdermal films for gabapentin hydrochloride to treat oncogenic neuropathic pain, showing 75.58% drug release in 12 hours.