Photodynamic Therapy Research Studies

Complementary cytotoxicity of GD2-targeted photoimmunotherapy and 5-aminolevulinic acid photodynamic therapy in neuroblastoma and osteosarcoma

This study combines GD2-targeted photoimmunotherapy and 5-aminolevulinic acid photodynamic therapy to enhance cytotoxicity and reduce light-dose requirements in neuroblastoma and osteosarcoma.

Common Ground in Chaos: Diversified Photodynamic Treatments Converge on a Unified Stress Architecture in Escherichia coli

This study identifies a shared stress response in E. coli across diverse photodynamic treatments, revealing conserved gene expression patterns and potential therapeutic targets.

Understanding the role of membrane lipids in mechanism of antimicrobial photodynamic therapy in Escherichia coli

This study shows that reducing cardiolipin in Escherichia coli increases its susceptibility to antimicrobial photodynamic therapy, suggesting cardiolipin-rich domains support stress-defense systems rather than being direct targets of oxidative damage.

Photodynamic priming with Vitamin D and ALA-based PDT induces intratumoral immune cell recruitment and signaling pathway activation in murine cutaneous squamous cell carcinoma

This study shows that combining Vitamin D with aminolevulinic acid-based photodynamic therapy enhances immune cell recruitment and signaling pathways in murine cutaneous squamous cell carcinoma.

Time-resolved transcriptomic mapping reveals conserved stress programs and metabolic rewiring in Escherichia coli under antimicrobial photodynamic and blue light exposure.

This study uses time-resolved transcriptomics to show how E. coli responds to different photodynamic stresses, revealing common acute stress responses and divergent long-term adaptations.

Cationic heme-mimetic gallium porphyrin kills bacteria and disrupts biofilms

This study evaluates a cationic gallium porphyrin for its ability to kill bacteria and disrupt biofilms, showing no resistance development after 20 passages.

Quantitative evaluation of growth rate and survival of planktonic yeast under dual-parameter photodynamic treatment

The paper evaluates the effect of dual-parameter photodynamic treatment on yeast growth and survival using exponential phase coefficients.

Intra-Abdominal Photodynamic Therapy in a Rabbit Model of Perforated Appendicitis

This paper evaluates the feasibility and safety of laparoscopic methylene blue photodynamic therapy (MB-PDT) in a rabbit model of perforated appendicitis, showing no off-target injury and in vitro antimicrobial efficacy.

Curcumin-mediated photodynamic inactivation of Escherichia coli, Pseudomonas fluorescens, and Candida auris

This study evaluates curcumin-mediated photodynamic therapy's effectiveness against E. coli, P. fluorescens, and C. auris, showing varying efficacy based on microbial species and light dose.

In Silico Study of Active Delivery of a Photodynamic Therapy Drug Targeting the Folate Receptor

The paper uses molecular dynamics simulations to study how a PDT drug conjugated with folic acid interacts with the folate receptor, showing stable complex formation and unchanged optical properties.

Quantitative Fluorescence Imaging of Porphyrin Phospholipid Photobleaching and Light Activated Liposomal Doxorubicin Release Using Wide-field and Laparoscopic SFDI in an Ovarian Cancer Model

This paper develops a laparoscopic SFDI system to monitor porphyrin phospholipid photobleaching and doxorubicin release in an ovarian cancer model, demonstrating its potential for real-time intraoperative monitoring of chemophototherapy.

Ru(II)-Photoactive Agents for Targeting ER Stress and Immunogenic Cell Death

This paper evaluates two Ru(II) photoactive agents, showing compound 2 induces ER stress and immunogenic cell death in cancer cells and elicits anti-tumor immunity in vivo.