Author

Mackenzie K. Herroon

Wayne State UniversityORCID 0000-0001-6565-9074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Izabela PodgorskiiD· 3 shared Alexis Wilson· 2 shared Shane Mecca· 2 shared Alexander Ullrich· 1 shared Claudia TurróiD· 1 shared Gioia HeraviiD· 1 shared Heather Marie GibsoniD· 1 shared Jacob Lindquist· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Izabela PodgorskiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Targeting SCD in SCD-amplified prostate cancer inhibits growth in bone by modulating cellular stress, mTOR, and DNA damage pathways

Alexis Wilson, Mackenzie K. Herroon, Shane Mecca, Laimar C. Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski

This study shows SCD inhibition in prostate cancer reduces tumor growth in bone by affecting cellular stress, mTOR, and DNA damage pathways.

bioRxiv · Jun 9, 2025 · PreprintCancer Biology

Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response

Gioia Heravi, Zhenjie Liu, Mackenzie K. Herroon, Alexis Wilson, Yang-Yi Fan, Yang Jiang, Nivisa Vakeesan, Tao Li, Zheyun Peng, Kezhong Zhang, Jing Li, Robert S. Chapkin, Izabela Podgorski, Wanqing Liu

This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Biomedicine & Pharmacotherapy · Mar 23, 2025Peer-reviewedCancer Biology

Ru(II)-Photoactive Agents for Targeting ER Stress and Immunogenic Cell Death

Madeline Denison, Alexander Ullrich, Mackenzie K. Herroon, Shane Mecca, Claudia Turró, Izabela Podgorski, Heather Marie Gibson, Jeremy J. Kodanko

This paper evaluates two Ru(II) photoactive agents, showing compound 2 induces ER stress and immunogenic cell death in cancer cells and elicits anti-tumor immunity in vivo.

bioRxiv · Jul 18, 2024 · PreprintCancer Biology