Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1
Wenjun Guo, Miao Wei, Yunfeng Li, Jiaxuan Xu, Jiahe Zang, Yuezhou Chen, Lei Chen
Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.
Nature Communications · Feb 10, 2025Peer-reviewedBiochemistry✦ In-depth digest