Gout, Hyperuricemia, Uric Acid

DNA methylation reveals molecular heterogeneity and urate excretion-associated subtypes of gout

The paper identifies DNA methylation subtypes of gout associated with urate excretion using methylation profiling and machine learning, achieving high predictive performance.

Prevotella copri alleviates hyperuricemia via uricolysis and gut microbiota reconstruction

This study identifies Prevotella copri as a strain that alleviates hyperuricemia through uric acid catabolism and restoration of uric acid-consuming gut bacteria.

A circRNA-based uricase replacement therapy for sustained treatment of hyperuricemia

This study develops a circRNA-based uricase replacement therapy that reduces serum urate levels and maintains efficacy for up to 10 weeks in uricase-knockout mice.

Molecular determinants of selective and high-affinity binding of the scaffold protein PDZK1 to the transporter URAT1

This study identifies molecular determinants of high-affinity PDZK1 binding to URAT1 using biophysical and structural methods, revealing species-specific interactions.

Testing for Causal Association between Serum Urate, Gout, and Prostatic Cancer in European Males

The paper uses Mendelian randomization to test causal links between serum urate, gout, and prostate cancer in European males, finding a causal effect of gout on prostate cancer but not of urate.

XDH-1 inactivation causes xanthine stone formation in C. elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell

This paper identifies sulp-4 as a critical gene controlling xanthine stone accumulation in C. elegans by mediating sulfate transport, and shows its interaction with sulfur amino acid metabolism and osmotic stress pathways.

The Genetic Immune Basis of Gout: Identification, Functional Characterization, and Therapeutic Implications

This study identifies and characterizes immune-related genetic factors in gout, showing their potential as therapeutic targets beyond traditional urate-lowering treatments.

A Reductive Uric Acid Degradation Pathway in Anaerobic Bacteria

This paper identifies a reductive uric acid degradation pathway in E. coli and demonstrates its therapeutic potential in reducing uric acid levels in mice.

Molecular basis of the urate transporter URAT1 inhibition by gout drugs

This study determines the cryo-EM structures of URAT1 with inhibitors and reveals their binding mechanisms and conformational changes.

Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs

This study presents cryo-EM structures of hURAT1 bound with anti-gout drugs and uric acid, revealing transport mechanisms and drug inhibition.

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.

Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)

This study identifies 13 genetic loci associated with gout using GWAS in the UK Biobank, with four novel loci, and finds sex-specific genetic influences and associations with metabolic and immune traits.

Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

This study shows that host-derived Lactobacillus plantarum strain SQ001 alleviates hyperuricemia by improving gut microbiota and enhancing purine nucleoside degradation.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

Locus-specific stratification and prioritization unveil high risk genes underlying hyperuricemia

This study introduces a method to identify causal genes and regulatory mechanisms in hyperuricemia by integrating single-cell data with genetic findings.

Identification of three distinct cell populations for urate excretion in human kidney

The paper identifies three distinct cell populations in human kidney tubules involved in urate handling, showing heterogeneity in transporter expression and function.

Insulated expression of periplasmic uricase in E. coli Nissle 1917 for the treatment of hyperuricemia

This study engineered an E. coli probiotic to express periplasmic uricase in an insulated site, showing efficacy in reducing hyperuricemia in animal models without affecting probiotic properties.

LncRNA s Landscape in the patients of primary gout by Microarray Analysis

This study identifies differentially expressed lncRNAs and mRNAs in gout patients using microarray analysis and validates potential diagnostic biomarkers.

Evaluation of the causal effects of blood lipid levels on gout with summary level GWAS data: two-sample Mendelian randomization and mediation analysis

This paper uses Mendelian randomization and mediation analysis to evaluate the causal effects of blood lipid levels on gout using summary-level GWAS data, finding that HDL and TG influence gout risk through serum urate.

Pleiotropic effect of ABCG2 in gout: involvement in serum urate levels and progression from hyperuricemia to gout

This study investigates the role of ABCG2 variants in gout progression from hyperuricemia, finding a stronger association with gout than with urate levels.

Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.

This paper identifies 15 novel serum urate loci and links them to 44 genes, revealing new molecular mechanisms of urate control through genomic and eQTL analysis.

Genetic predisposition to hypouricemia on whole-exome sequencing analysis and its utilities in primary screening purposes

This paper uses whole-exome sequencing to identify genetic markers for hypouricemia and shows that screening two SNPs can detect 87.7% of cases.

PKD2 influence uric acid levels and gout risk by interacting with ABCG2

This study identifies epistatic interactions between PKD2 and ABCG2 influencing uric acid levels and gout risk, with gender and BMI-dependent effects.