Gout, Hyperuricemia, Uric Acid

Molecular determinants of selective and high-affinity binding of the scaffold protein PDZK1 to the transporter URAT1

This study identifies molecular determinants of high-affinity PDZK1 binding to URAT1 using biophysical and structural methods, revealing species-specific interactions.

Testing for Causal Association between Serum Urate, Gout, and Prostatic Cancer in European Males

The paper uses Mendelian randomization to test causal links between serum urate, gout, and prostate cancer in European males, finding a causal effect of gout on prostate cancer but not of urate.

XDH-1 inactivation causes xanthine stone formation in C. elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell

This paper identifies sulp-4 as a critical gene controlling xanthine stone accumulation in C. elegans by mediating sulfate transport, and shows its interaction with sulfur amino acid metabolism and osmotic stress pathways.

A Reductive Uric Acid Degradation Pathway in Anaerobic Bacteria

This paper identifies a reductive uric acid degradation pathway in E. coli and demonstrates its therapeutic potential in reducing uric acid levels in mice.

Molecular basis of the urate transporter URAT1 inhibition by gout drugs

This study determines the cryo-EM structures of URAT1 with inhibitors and reveals their binding mechanisms and conformational changes.

Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs

This study presents cryo-EM structures of hURAT1 bound with anti-gout drugs and uric acid, revealing transport mechanisms and drug inhibition.

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.

Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

This study shows that host-derived Lactobacillus plantarum strain SQ001 alleviates hyperuricemia by improving gut microbiota and enhancing purine nucleoside degradation.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

Identification of three distinct cell populations for urate excretion in human kidney

The paper identifies three distinct cell populations in human kidney tubules involved in urate handling, showing heterogeneity in transporter expression and function.

LncRNA s Landscape in the patients of primary gout by Microarray Analysis

This study identifies differentially expressed lncRNAs and mRNAs in gout patients using microarray analysis and validates potential diagnostic biomarkers.

Evaluation of the causal effects of blood lipid levels on gout with summary level GWAS data: two-sample Mendelian randomization and mediation analysis

This paper uses Mendelian randomization and mediation analysis to evaluate the causal effects of blood lipid levels on gout using summary-level GWAS data, finding that HDL and TG influence gout risk through serum urate.

Pleiotropic effect of ABCG2 in gout: involvement in serum urate levels and progression from hyperuricemia to gout

This study investigates the role of ABCG2 variants in gout progression from hyperuricemia, finding a stronger association with gout than with urate levels.

Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.

This paper identifies 15 novel serum urate loci and links them to 44 genes, revealing new molecular mechanisms of urate control through genomic and eQTL analysis.