Transplanted hearts assimilate the recipient's biological age
Jesse R. Poganik, Tomohisa Matsunaga, Alexander Tyshkovskiy, Ake Tzu-Hui Lu, Amin Haghani, Hao Zhou, Friederike Martin, Steve Horvath, Michael M. Givertz, Stefan G. Tullius, Vadim N. Gladyshev
DNA methylation clocks show heterochronic heart grafts shifting toward recipient age in syngeneic mice and 11 human recipients, while recipient mouse native heart, liver and blood show no consistent change.
bioRxiv · Sep 17, 2026 · PreprintSystems Biology✦ In-depth digest