Amin Haghani

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

DNA methylation clocks show heterochronic heart grafts shifting toward recipient age in syngeneic mice and 11 human recipients, while recipient mouse native heart, liver and blood show no consistent change.

This study develops epigenetic clocks for axolotls, revealing biphasic age prediction during early life but not later, and highlights methylome stability across lifespan.

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

The paper compares DNA methylation age in four premature aging mouse models, finding ERCC1 mice show the most significant increase in epigenetic age.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

This study shows biological age can increase with stress and decrease with recovery, using epigenetic clocks in mice and humans.

The paper identifies a regulatory hotspot, meQTL.5a, that influences DNA methylation, gene expression, and aging traits in mice through genetic and age-related factors.

The paper compares morphological and DNA methylation differences between island and mainland masked shrews, finding epigenetic and phenotypic divergence.

This paper develops an epigenetic clock for humpback whales using DNA methylation data, showing high accuracy for known ages but underestimation in older individuals and applicability to beluga whales.

The paper develops DNA methylation clocks for clawed frogs, showing evolutionary conservation of epigenetic ageing mechanisms between frogs and mammals.

The paper identifies gastrulation in Xenopus laevis as the stage with the lowest epigenetic age and highest developmental disruption, suggesting it as the onset of aging.

This study identifies genetic loci and metabolic factors associated with epigenetic aging in mice, showing links between DNA methylation entropy, diet, and life expectancy.

The paper develops a mammalian methylation array to profile methylation levels at conserved sequences across species, enabling cross-species comparisons and epigenetic biomarker development.

This paper develops epigenetic clocks for horses using DNA methylation data from multiple tissues, showing age-related CpGs are near developmental genes and that castration does not significantly affect aging rate.

This study develops DNA methylation-based age estimators for deer mice using genome-wide data, showing how age, sex, genetic relatedness, and tissue type influence methylation patterns.

The paper develops DNA methylation-based age estimators for vervet monkeys and shows evolutionary conservation of epigenetic aging in primates.

The paper develops epigenetic clocks for pigs and identifies methylation differences between domestic and minipigs, linking them to obesity and aging-related genes.

The paper develops methylation-based age estimation clocks for bottlenose dolphins using blood and skin samples, achieving high accuracy with median absolute errors under 3 years.

This paper develops epigenetic clocks for rhesus macaques using methylation data from multiple tissues, showing high cross-species correlation with vervet monkeys.

This paper develops epigenetic clocks for common marmosets using DNA methylation data and tests rapamycin's effect on epigenetic age, finding no significant impact.

This paper develops epigenetic clocks for domestic cats using methylation profiles from a custom Infinium array, creating three clocks including dual-species human-cat clocks.

This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.

This paper develops epigenetic clocks for African and Asian elephants using DNA methylation data to estimate age and identify age-related CpGs and their associated genes.

This paper develops epigenetic clocks for bovine oocytes and evaluates their ability to estimate chronological age and reveal differences in aging between oocytes and blood.

This paper develops epigenetic clocks for dogs to estimate age and mortality risk, and identifies methylation sites linked to breed weight and lifespan.

The paper develops epigenetic clocks and pacemaker models to predict age in plains zebras and other equids using DNA methylation data from blood samples.

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.