Transplantation: Methods and Outcomes

Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

Aberrant and Ectopic Cell Populations of the Fibrotic Pushing Border in Restrictive Allograft Syndrome after Lung Transplantation

This study identifies aberrant cell populations in RAS lungs using snRNA-seq and histology, revealing a fibrotic niche composed of specific cell types with potential therapeutic targets.

Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection

The paper identifies conserved gene signatures predictive of allograft rejection across multiple organs using transcriptomic data and machine learning.

Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosis

Evaluation of Ventilation at 10C as the Optimal Storage Condition for Donor Lungs in a Murine Model

This study evaluates ventilation at 10°C for preserving donor lungs in mice, finding it reduces injury and improves function compared to static storage at 4°C or 10°C.

Left ventricular transcriptome and extracellular vesicle-derived miRNAs in porcine donation after circulatory death (DCD) hearts undergoing prolonged working mode ex situ perfusion

The paper identifies transcriptional changes in porcine DCD hearts during prolonged ESHP and shows cardioprotection reduces maladaptive gene expression and increases beneficial miRNA release.

Proteomic analysis of bronchoalveolar lavage fluid after lung transplantation associates stable allograft function with less lung damage at 12 months

The paper identifies proteomic differences in bronchoalveolar lavage fluid at 12 months post-lung transplant that correlate with stable graft function versus early chronic lung allograft dysfunction.

Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation.

This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.

It takes two: Aberrant repair and low-grade inflammation characterizes bronchiolitis obliterans syndrome after lung transplantation in serum proteomic analysis

This study identifies protein expression differences in serum associated with fibrosis and inflammation in bronchiolitis obliterans syndrome after lung transplantation.

Characteristics of human donor lungs utilized for research

This study characterizes donor lungs used for research, finding higher prevalence of diabetes, smoking, and non-intravenous drug use compared to transplant lungs.

CAR Treg synergy with anti-CD154 mediates infectious tolerance to dictate heart transplant outcomes.

This study shows that A2-specific CAR Tregs synergize with anti-CD154 to promote graft survival in haplo-mismatched heart transplants by inhibiting donor-specific immune responses.

Single-cell RNA-sequencing identifies unique cell-specific gene expression profiles in high-grade cardiac allograft vasculopathy

The paper uses single-cell RNA-sequencing to identify cell-specific gene expression patterns in high-grade cardiac allograft vasculopathy, finding increased CD4+ T central memory cells and monocytes, and 745 differentially expressed genes.

Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathy

Identification of Cell-Free DNA Methylation Patterns Unique to the Human Left Ventricle as a Potential Indicator of Acute Cellular Rejection

The paper identifies ventricle-specific DNA methylation patterns in cell-free DNA that correlate with acute cellular rejection in heart transplant recipients.