Bone health and treatments

An immunocompetent osteoblastic model of mammary cancer bone metastasis established by syngeneic intratibial injection of PyMT mammary carcinoma cells in FVB/N mice

This paper develops an immunocompetent mouse model of osteoblastic breast cancer bone metastasis using PyMT-CK(OB) cells and validates its utility for studying immune-dependent bone remodeling mechanisms.

Single-cell RNA sequencing reveals collagen interactions between detached osteoclasts and activated fibroblasts in granulation tissue surrounding sequestra in medication-related osteonecrosis of the jaw

This study uses scRNA-seq to identify detached osteoclasts in MRONJ granulation tissue and reveals collagen-mediated interactions with fibroblasts.

A New Class of Precision Therapeutics that Inhibit Prostate Cancer Mediated Bone Destruction

This paper develops BTE-EN1, a compound that inhibits prostate cancer-mediated bone destruction by targeting cell motility and osteoclast activity, showing efficacy in mice.