Connexins and lens biology

PARIS is an optogenetic tool that enables high-resolution mapping of functional gap junctions in cultured cells and Drosophila neurons.

The paper presents a framework to model intercellular calcium wave propagation in astrocyte networks and investigates how network topologies affect wave characteristics.

The paper maps heterocellular coupling between ganglion cells and amacrine cells in the mammalian retina using high-resolution TEM and identifies specific coupling patterns and metabolic interactions.

The paper investigates how dopamine maintains network synchrony in crab cardiac ganglion neurons by modulating gap junctions, preventing desynchronization caused by serotonin or K+ channel blockers.

This study shows that misexpression of ShakB isoforms in Drosophila JONs alters gap junction formation with the GF but not chemical synapses, with ShakB(N+16) increasing gap junctions and ShakB(N) abolishing dye coupling.

The paper identifies Tjp1b as an intracellular scaffold required for electrical synapse formation and shows its asymmetric localization and function at the postsynaptic side.

The paper identifies a genetic basis for molecular asymmetry at vertebrate electrical synapses in zebrafish, showing that two Connexins function presynaptically and postsynaptically, respectively, and are required for escape responses.