Cytokine Signaling Pathways and Interactions

Single-cell profiling quantifies the dose gap between population-average and complete pY-STAT1/3 suppression by JAK inhibitors

The paper quantifies the discrepancy between population-average and single-cell suppression of pY-STAT1/3 by JAK inhibitors, showing that strong average suppression leaves many cells with elevated responses.

Graded and cross-reactive JAK-receptor interactions broaden the one-receptor, one-JAK rule

The paper tests the one-receptor, one-JAK model by measuring JAK1 and TYK2 interactions with receptor ICDs, finding graded and cross-reactive binding rather than exclusive, constitutive interactions.

An IL-21R STAT hypomorph circumvents functional redundancy in germinal center responses

This study identifies an IL-21R hypomorph mutation that specifically impairs STAT1 activation, revealing a nonredundant role for IL-21 in Tfh cell differentiation.