Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy
Vinay R. Penna, Junedh Amrute, Morgan Engel, Emily A. Shiel, Waleed Farra, Elisa Nicole Cannon, Colleen Leu-Turner, Pan Ma, Ana Villanueva, Hae-Won Shin, Alekhya Parvathaneni, Joanna Jager, Carlos Bueno‐Betí, Angeliki Asimaki, Kory J. Lavine, , Stephen P. Chelko
Human arrhythmogenic cardiomyopathy hearts harbor a lesion niche of POSTN fibroblasts and NLRP3+ inflammatory macrophages; IL-1β neutralization in Dsg2-mutant mice reduced fibrosis, dysfunction, and ventricular ectopy.
JACC Basic to Translational Science · May 5, 2026Peer-reviewedImmunology✦ In-depth digest