High Altitude and Hypoxia

Baseline psychological traits contribute to Lake Louise Acute Mountain Sickness score at high altitude

The paper shows that baseline psychological traits like anxiety and neuroticism, not physiological changes, are linked to AMS symptoms at high altitude.

Role of mitochondrial genetic interactions in determining adaptation to high altitude in human population around the globe

The paper models mitochondrial polymorphisms as co-mutation networks in three high-altitude populations to identify functionally enriched genetic interactions associated with high-altitude adaptation.

An exploration of metabolic and transcriptional responses in mouse skeletal muscles responding to acute sedentary hypoxia

This study examines metabolic and transcriptional changes in mouse skeletal muscles under acute sedentary hypoxia, finding moderate metabolic responses with weak gene-metabolite correlations, but significant glutamine metabolism changes.

Hypoxia-tolerant vascular endothelial growth factor-A (VEGF-A) and the genetic variations of VEGFA in Sherpa highlanders

This study examines VEGF-A levels and genetic variations in Sherpa highlanders and non-Sherpa lowlanders, finding no hypoxia response in Sherpas and significant genetic differences in VEGFA SNPs.

HAHmiR.DB : A Server Platform For High Altitude Human miRNA-Gene Coregulatory Networks And Associated Regulatory-Circuits.

HAHmiR.DB provides a database and server platform for miRNA-gene coregulatory networks and regulatory circuits associated with high altitude stress.

A Key For Hypoxia Genetic Adaptation In Alpaca Could Be A HIF1A Truncated bHLH Protein Domain

The paper identifies genetic truncations in the HIF1A bHLH domain in Alpacas and Cetartiodactyls, suggesting a shared evolutionary adaptation to hypoxia.

DNA Methylation Explains a Subset of Placental Gene Expression Differences Based on Ancestry and Altitude

The paper examines how DNA methylation influences gene expression differences in placental tissue between Andean and European ancestry individuals at high and low altitudes, finding more methylation regulation in ancestry-related genes.

Using composite phenotypes to reveal hidden physiological heterogeneity and model oxygen saturation variation of high altitude acclimatization in a Chinese Han longitudinal cohort

Deciphering Molecular Cascades In A Novel Acclimatization Strategy For Rapid Ascent To High Altitude

This study examines the effects of acute high-altitude exposure on lung and plasma in rats, identifying redox stress responses and a rapid acclimatization protocol that improves survival at extreme altitudes.