Jiucun Wang

This paper proposes a context-dependent framework for variant interpretation by analyzing LPL loss-of-function variants, showing how residual activity levels influence clinical outcomes.

The paper develops and validates multi-ancestry polygenic risk scores for LUAD in East Asian never-smokers, showing improved risk prediction compared to East Asian-only models.

This study identifies the assembly rules of the human skin microbiome and shows that host lipids drive microbial niche partitioning through lipid metabolism.

The paper uses spatial transcriptomic methods to identify novel fibroblast subpopulations in systemic sclerosis skin and their pathogenic roles.

The paper identifies novel structural variants in Han Chinese genomes using long-read sequencing and links them to phenotypic diversity and disease susceptibility.

The paper introduces Limpute, an efficient algorithm for genotyping common variants from low-coverage sequencing data, achieving high imputation accuracy with faster runtime than GLIMPSE2.

This study identifies genetic differences in HAPC susceptibility between Tibetans and Han Chinese using GWAS, revealing distinct pathways involved in each group.

This paper introduces ratio-based multiomics profiling using universal reference materials to improve data integration across omics types and batches.

This paper introduces a new statistical method for GWAS that improves power and reduces false positives by using large public databases as references.

The paper evaluates the antifibrotic effects of triple siRNA targeting SPARC, CCR2, and SMAD3 in a mouse model of fibrosis, showing reduced inflammation and fibrosis through multi-target intervention.

This study identifies epistatic interactions between PKD2 and ABCG2 influencing uric acid levels and gout risk, with gender and BMI-dependent effects.

This study identifies Denisovan introgressions in Papua New Guineans and Australians, finds they are under positive selection and related to important evolutionary functions, and proposes a method for detecting archaic hominin introgressions.