High Altitude and Hypoxia

Comparative and population genomics analyses of eared pheasants inhabiting highly varying altitudes

The paper compares genome sequences and genetic variations of three eared pheasant species at different altitudes to identify adaptation mechanisms.

Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure

This study investigates immune and metabolic changes in individuals adapting to high altitude using single-cell transcriptomics and metabolomics, revealing immune activation and metabolic shifts linked to adaptation.

Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

Elevational variation in heart mass and suppression of hypoxia-induced right ventricle hypertrophy in Andean leaf-eared mice (Phyllotis)

The paper examines elevational variation in heart mass and RV hypertrophy in Andean leaf-eared mice, finding that suppression of RV hypertrophy is linked to differential gene expression in high-altitude populations.

Association between EPAS1 and ATP6V1E2 Polymorphisms and Susceptibility to High Altitude Polycythemia in Chinese Tibetan Population

This study identifies genetic polymorphisms in EPAS1 and ATP6V1E2 associated with susceptibility to high altitude polycythemia in Tibetan populations.

Effect of high-altitude exposure on skeletal muscle mitochondrial subcellular distribution, ultrastructure and respiration in sea-level residents

This study examines how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, and respiratory capacity in sea-level residents.

Transcriptomic study of testicular hypoxia adaptation in Tibetan sheep

This study identifies differentially expressed genes and pathways in Tibetan sheep testicular tissue under hypoxia, suggesting their role in reproductive adaptation to high altitude.

Multi-omics Reveals Immune Response and Metabolic Profiles during High-Altitude Mountaineering

This study uses multi-omics data to analyze immune and metabolic changes in mountain climbers during acclimatization and extreme altitude exposure.

Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice

This study compares the thermogenic capacity of highland and lowland deer mice under increasing hypoxia to assess the roles of local adaptation and plasticity in high-altitude tolerance.

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

This study generates a time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues in sheep, identifying key genes and regulatory elements involved in hypoxia adaptation.

Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice

The paper examines gene expression changes in highland deer mice exposed to hypoxia at different developmental stages, identifying differentially expressed gene suites and transcriptional modules linked to respiratory traits and altitude adaptation.

High-altitude adaptation and incipient speciation in geladas

This study identifies genomic and karyotypic changes in geladas that may contribute to high-altitude adaptation and speciation.

Baseline psychological traits contribute to Lake Louise Acute Mountain Sickness score at high altitude

The paper shows that baseline psychological traits like anxiety and neuroticism, not physiological changes, are linked to AMS symptoms at high altitude.

Role of mitochondrial genetic interactions in determining adaptation to high altitude in human population around the globe

The paper models mitochondrial polymorphisms as co-mutation networks in three high-altitude populations to identify functionally enriched genetic interactions associated with high-altitude adaptation.

HAHmiR.DB : A Server Platform For High Altitude Human miRNA-Gene Coregulatory Networks And Associated Regulatory-Circuits.

HAHmiR.DB provides a database and server platform for miRNA-gene coregulatory networks and regulatory circuits associated with high altitude stress.