Hepatitis Viruses Studies and Epidemiology

A porcine chronic hepatitis E virus (HEV) infection model exhibits HEV replication in male accessory reproductive glands and immune-mediated reproductive damage

This study shows HEV replicates in male accessory reproductive glands and sperm cells of chronically infected pigs, causing immune-mediated reproductive damage and potential sexual transmission.

Functional study of two flexible regions of the hepatitis E virus ORF1 replicase

This study investigates two flexible regions of the HEV ORF1 replicase using structural modeling and mutagenesis, showing their functional importance in viral replication.

An optimized model for HEV infection in the HepaRG cell line

This study shows that HepaRG cells can be infected by HEV without DMSO treatment, making them a suitable model for studying HEV and its interaction with hepatocyte innate immunity.

Network controllability analysis reveals the antiviral potential of Etravirine against Hepatitis E Virus infection

This study identifies CK1ε as an antiviral target for HEV and shows that Etravirine, an HIV drug, inhibits CK1ε to exhibit antiviral activity against HEV.

High performance enrichment-based genome sequencing to support the investigation of hepatitis A virus outbreaks

This paper introduces a hybrid capture enrichment assay for whole genome sequencing of HAV, improving sensitivity and enabling outbreak investigation.