Hepatitis Viruses Studies and Epidemiology

The proteasome and ERAD pathways can regulate hepatitis E virus pORF1 proteostasis and genome replication

This study identifies the ERAD and proteasome pathways as regulators of HEV pORF1 proteostasis and genome replication.

Impact of hepatitis E virus host- and virus-derived insertions on the antiviral response in primary human hepatocytes

This study examines how different HEV HVR insertion variants affect host transcriptomic responses in PHHs, finding that HVR duplication variants elicit weaker host responses and reduced ISG induction.

ZDHHC17-Mediated Palmitoylation of Hepatitis E Virus ORF3 Protein Regulates Vectorial Trafficking in Polarized Epithelial Cells

This study identifies ZDHHC17-mediated palmitoylation of HEV ORF3 protein as critical for directional secretion in polarized epithelial cells.

Rat hepatitis E virus infection has multiphasic viral replication kinetics in vivo

This study characterizes the multiphasic viral replication kinetics of rat HEV in vivo, showing liver as the main replication site and ribavirin's partial efficacy in preventing viral rebound.

The effects of denifanstat on hepatitis E virus replication and triggered inflammatory response

This study evaluates denifanstat's effects on HEV replication and inflammatory responses in steatotic liver organoids and macrophages, finding moderate antiviral activity in macrophages but not in organoids.

The nucleotide analog bemnifosbuvir inhibits hepatitis E virus replication in preclinical models

This study identifies bemnifosbuvir as a potent inhibitor of hepatitis E virus replication in vitro and in a gerbil model, with additive effects when combined with ribavirin.

Auranofin Inhibits Hepatitis E Virus Replication Via Reactive Oxygen Species

This paper identifies auranofin as an effective in vitro inhibitor of HEV, showing antiviral activity against multiple genotypes and a ribavirin-resistant mutant, with ROS-mediated mechanism.