Pharmacological Effects and Toxicity Studies

Investigation into the effects of sodium valproate on prepubertal mouse gonads in vivo

This study examines the effects of sodium valproate on prepubertal mouse gonads, finding no significant gonadotoxicity but a trend toward reduced germ cell density in males.

Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

This study shows that maternal exposure to low environmental levels of carbamazepine causes mild growth retardation in mouse embryos without affecting survival or gross malformations.

A replication study on key neurodevelopmental pathways affected by valproate treatment ofneural precursor cells

This study replicates and extends findings on valproate's effects on neural precursor cells by identifying common differentially expressed genes and enriched signaling pathways.

Carbamazepine Causes Changes in Maternal Reproductive Performance and Fetal Growth Retardation in Rats

This study investigates the effects of carbamazepine on maternal reproductive outcomes and fetal development in rats, finding reduced fetal weight, implantation rates, and increased congenital malformations.