Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission
Jeffri S. Retamal, Shane D. Hellyer, Paulina D. Ramírez-García…·Nicholas A. Veldhuis
This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.