Justin John Cooper-White

Marrow-mimicry MEW scaffolds recapitulate erythroblastic islands for high-density cRBC biomanufacturing

This study develops marrow-mimic scaffolds that enhance cRBC production by supporting macrophage-erythroblast interactions in high-density cultures.

Spatially distributed growth factor environments for evaluating hydrogel-based CD34+ cell culture conditions

This paper presents a microfluidic system to create spatial growth factor gradients in hydrogels for studying CD34+ cell behavior and optimizing culture conditions.

Transmitted alpha-synuclein extracellular vesicles downregulate axonal flux of retrograde carriers in recipient neurons

This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

This study shows that Down syndrome brain organoids with choroid plexus defects enhance SARS-CoV-2 neurotropism, which can be inhibited by targeting TMPRSS2 and Furin.

Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.

Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations

This study identifies three distinct senescent subpopulations in human mesenchymal stem cells using single-cell RNA sequencing, revealing potential drug targets for senescence delay.

Self-Organizing 3D Human Choroid Plexus-Ventricle-Cortical Organoids

This paper describes the development of 3D human organoids that simultaneously generate choroid plexus and cortical cells, recapitulating key features of forebrain development.