Sean D. Morrison

This study uses brain organoids to show trisomy 21 impairs oligodendrocyte maturation and neural network function in Down syndrome.

This study shows SARS-CoV-2 infects hiPSC-derived neurons via endosomal-lysosomal pathway dependent on cathepsins, leading to HIF1alpha accumulation and phosphorylated tau, suggesting neurodegenerative effects.

This study shows that Down syndrome brain organoids with choroid plexus defects enhance SARS-CoV-2 neurotropism, which can be inhibited by targeting TMPRSS2 and Furin.

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.