An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Eloïse Marques, Stephen P. Burr, Alva M. Casey, Richard J Stopforth, Chak Shun Yu, Keira Turner, Dane M. Wolf, Marisa Dilucca, Victoria J. Tyrrell, Robbin Kramer, Yamini M Kanse, Christopher A. Powell, James Bruce Stewart, Michael P. Murphy, Michal A. Minczuk, , Dylan G. Ryan
This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.
bioRxiv · Jan 5, 2025 · PreprintImmunology