Stuttering Research and Treatment

Fixel-wise Differences in White Matter Fiber-bundle Cross-section identified in Children who Stutter

This study uses fixel-based analysis to examine white matter differences in children who stutter compared to controls, finding significant group and age-related effects in fiber-bundle cross-section.

Striatal and frontal signatures of social context and cost-benefit decision making in developmental stuttering

This study examines how social context and decision-making affect neural activity in adults who stutter compared to controls using fMRI and behavioral tasks.

Unravelling the genetic basis of stuttering: GWAS meta-analysis highlights link with rare speech disorders

This study conducts a GWAS meta-analysis of stuttering, identifying genetic links with speech disorders and highlighting shared genetic architecture across different ascertainment methods.

Why Speech Motor Blocks Emerge in a Communicative Context: An Active Inference Model of Stuttering

This paper develops an active inference model of stuttering that explains private speech fluency and information-value effects in social contexts.

Functionally Oriented Genetic Analyses Reveal Potential Transcriptomic and Neurological Mechanisms of Stuttering

This study identifies transcriptomic and neurological mechanisms of stuttering using GWAS, TWAS, MR, and neuroimaging analyses of large datasets.

Implicit visuomotor adaptation to clamped feedback is reduced in adults who stutter

This study shows adults who stutter exhibit reduced implicit visuomotor adaptation during arm reaching tasks with clamped visual feedback compared to adults who do not stutter.

Neural subtypes in developmental stuttering

This study identifies four neural subtypes in children who stutter based on structural brain atypicalities, revealing distinct patterns associated with severity and recovery.

Structural Brain Correlates of Speech Disfluency in Early Childhood: A Dimensional Analysis in a Non-Clinical Cohort

This study examines the structural brain correlates of speech disfluency in 5-year-olds, finding associations between grey matter volume and disfluency without significant sex differences.

Non-vocal motor deficits in a transgenic mouse model linked to stuttering disorders

This study identifies non-vocal motor deficits in a Gnptab transgenic mouse model, linking lysosomal dysfunction to stuttering-related motor impairments.

Iron dysregulation in mice engineered with a mutation associated with stuttering

This study shows that a Gnptab mutation in mice leads to iron accumulation in the basal ganglia, which is linked to vocalization symptoms that improve with iron chelation.

Differences in brain activity during sentence repetition in people who stutter: a combined analysis of four fMRI studies

This study pools fMRI data from four studies to compare brain activity during sentence repetition in people who stutter and fluent controls, finding some group differences at uncorrected thresholds.

EEG responses to auditory cues predict fluency variability and stuttering intervention outcome

This study uses EEG to show that auditory cortical responses predict stuttering variability and response to speech therapy.

De novo protein-coding gene variants in developmental stuttering

The paper identifies de novo protein-coding gene variants in stuttering and highlights genetic links to neurodevelopmental disorders.

Does over-reliance on auditory feedback cause disfluency? An fMRI study of induced fluency in people who stutter.

This study investigates whether over-reliance on auditory feedback causes stuttering by comparing neural responses in people who stutter during different speech conditions.

Leveraging big data for classification of children who stutter from fluent peers

This study uses large neuroimaging datasets to develop a predictive model classifying children who stutter from fluent peers, achieving 72% accuracy.

An fMRI study of initiation and inhibition of manual responses in people who stutter

This study uses fMRI to compare neural activity during response initiation and inhibition in people who stutter versus typically fluent individuals, finding overactivity in PWS during initiation but not inhibition.

Iceberg or cut off - how adults who stutter articulate fluent-sounding utterances

The paper examines articulation patterns in adults who stutter (AWS) and adults who do not stutter (ANS) during fluent-sounding utterances, finding no major differences in movement patterns between groups.