Simon E. Fisher

This study examines how cortical thickness and surface area contribute to cognitive ageing using longitudinal data from multiple cohorts, finding thickness declines more steeply and is more strongly linked to cognitive change.

This study conducts a GWAS meta-analysis of stuttering, identifying genetic links with speech disorders and highlighting shared genetic architecture across different ascertainment methods.

The paper uses connectopic mapping on UK Biobank data to analyze variation in language-related brain connectivity and identifies genetic loci associated with these patterns.

This study examines brain asymmetry in situs inversus totalis cases, finding no significant difference in functional asymmetries between genetically solved and unsolved cases, but altered structural asymmetries regardless of genetic cause.

This study identifies genetic factors influencing susceptibility to chills from art and music using large-scale genetic data from 15,606 individuals.

This study integrates brain structure and function to identify genetic loci associated with language-related brain components using UK Biobank data.

The paper investigates the phenotypic effects of archaic protein-altering variants in living humans using UK Biobank data, finding no significant differences in health or cognitive traits among carriers.

This study functionally characterizes SATB2 missense variants to identify distinct effects on chromatin binding and transcriptional activity, revealing partial loss-of-function and some variants with increased function.

The paper uses spatial transcriptomics to analyze left-right gene expression and cell type differences in mouse brain regions, finding transcriptional asymmetries but no significant cell type abundance differences.

This study uses a multivariate GWAS approach to identify genetic loci associated with reading ability and dyslexia, finding 35 new genome-wide significant loci and estimating SNP heritability at 24%.

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

The paper models shared genomic and environmental influences on cognitive, language, and social traits in children, identifying distinct domains with trait-specific correlations between genetic and environmental factors.

This study links preschool musicality to school-age communication abilities through genetic factors related to rhythmicity using polygenic scores and structural equation modeling.

The paper identifies distinct genetic pathways contributing to different aspects of music enjoyment using twin data.

This study presents the first spatial transcriptomic data from a chimpanzee brain, mapping gene expression and cell types in the frontal pole and integrating with single-nucleus transcriptomics to explore evolutionary differences.

This study shows CHD3 regulates BMP signaling during cranial neural crest cell specification by modulating chromatin accessibility and gene expression.

The paper identifies distinct brain structural impacts of polygenic dyslexia disposition in adults using large-scale population data.

The paper identifies de novo protein-coding gene variants in stuttering and highlights genetic links to neurodevelopmental disorders.

This study investigates the shared genetic architecture between rhythm and dyslexia using large-scale genome-wide association studies.

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

The paper uses imaging genetics to analyze functional connectivity in language networks, identifying genetic loci linked to language abilities, dyslexia, and handedness.

The paper identifies region-specific laminar gene expression patterns in language-related cortical areas and links them to structural connectivity and dyslexia risk.

This study investigates the role of CHD3 in human brain development using genetically modified organoids, finding it regulates synaptic development genes without affecting early neurogenesis.

This study identifies rare protein-altering variants in TUBB4B and other genes associated with left-handedness using exome data from over 300,000 individuals.

The paper identifies 28 genomic loci associated with endocranial globularity using imaging genomics data from over 33,000 adults and links them to brain development and other physiological systems.

The paper integrates neuroimaging genetic data with genomic annotations to identify SNP heritability enrichments in fetal brain enhancer elements linked to human sulcal structures.

The paper uses structural equation modeling to identify three genetic factors linked to language/cognition, behavior, and motor development in ASD, revealing novel associations and simplex-specific genetic overlaps.

The paper investigates genetic influences on inter-individual differences in the sensorimotor-association axis of cortical organisation using twin data from the Human Connectome Project.

The paper identifies 355 genomic loci associated with white matter connectivity in the human brain, linking them to neurodevelopmental processes and polygenic risk for brain disorders.

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.