Moyamoya disease diagnosis and treatment

Exosome-Derived Proteomic Signatures Highlight Pathogenic Mechanisms in Moyamoya Disease

This study identifies dysregulated proteins in serum-derived exosomes from Moyamoya disease patients, linking them to angiogenesis and vascular signaling pathways.

Xenium In Situ Profiling Uncovers HSPG-Dependent SULF1/VEGFR2 Signaling Mediating Vascular Remodeling in Moyamoya Disease

The paper uses spatial transcriptomics and functional experiments to show SULF1 enhances VEGFR2 signaling and vascular remodeling in Moyamoya Disease.

Spatial Multi-Omics Reveals Extracellular Matrix Remodeling and VSMC Phenotypic Switching in Moyamoya Disease

This study uses spatial multi-omics to show ECM remodeling and VSMC phenotypic switching in Moyamoya Disease, linking FN1-ITGA5-FAK pathway activation to metabolic changes in the intimal niche.

Organoid Modeling and Single-Cell Profiling Uncover the Migration Mechanism of Smooth Muscle Cells in Moyamoya Disease

This study uses organoid models and single-cell profiling to identify TUBA4A and TUBB4B overexpression as drivers of vascular smooth muscle cell dysfunction in Moyamoya Disease.

miR-486-3p ameliorates aging-related impaired angiogenesis in adult moyamoya disease by targeting Forkhead Box O4

This study shows miR-486-3p improves angiogenesis in Moyamoya disease by targeting FOXO4 to reduce senescence-associated secretory phenotype.

RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in Moyamoya disease

This study investigates how the RNF213 variant R4810K impairs autophagy in endothelial cells under oxygen-glucose deprivation, leading to dysfunction in Moyamoya disease.

Arg4810Lys Mutation in RNF213 among Eastern Indian Non-MMD Ischemic Stroke Patients: A Genotype-Phenotype Correlation

This study identifies the Arg4810Lys RNF213 variant in Eastern Indian non-MMD ischemic stroke patients, finding its association with family history, earlier onset, and recurrent stroke, but not cognitive decline.

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses.

This study investigates how RNF213 loss of function affects vascular cells, revealing changes in transcriptome and alternative splicing linked to MMD pathogenesis.

A Novel Model for Encephalomyosynangiosis Surgery after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

This paper describes a novel surgical procedure, encephalomyosynangiosis, for ischemic stroke in mice and shows it does not increase mortality and maintains graft viability.

New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance and Moyamoya disease

This study identifies RNF213 as a regulator of adipogenesis through the TNFα/PTP1B and PPARγ pathways, showing its role in obesity and insulin resistance.

RNF213 variation, a broader role in neurovascular disease in Caucasian and Japanese populations

The paper investigates RNF213 variation's role in neurovascular diseases across Caucasian and Japanese populations, finding linkage disequilibrium between SLC26A11 and RNF213 variants associated with ischemic stroke and aneurysms.