Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.
Kaja Plucińska, Charlotte R. Wayne, Henry Sanford, Boby Mathew, Nathalie Ropek, Stephanie M. Adaniya, Corey Model, Nicolás Gómez-Banoy, Ksenia Morozova, Xiongwen Cao, Jeffrey M. Friedman, Ken H. Loh, Paul Cohen, Ekaterina V. Vinogradova
A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.
Cell Reports · Jun 1, 2026Peer-reviewedPhysiology✦ In-depth digest