Jeffrey M. Friedman

Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits

This study uses single-cell multi-omics to identify OTP and NOVA1 as key regulators of leptin action in hypothalamic feeding circuits, revealing cell-type-specific transcriptional and regulatory changes.

Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.

Macronutrient Composition and Genetic Background Determine the Response to a Ketogenic Diet

This study shows that macronutrient composition and genetic background influence the response to a ketogenic diet in mice, with B6J mice losing weight on a low-protein KD due to increased GDF15 and LCN2 levels.

Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management

This study identifies a novel target for obesity treatment by showing that inhibiting GABAergic neurons in the dorsal raphe nucleus reduces body weight in diet-induced obese mice through thermogenesis.

Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits.

This paper introduces a magnetogenetic method to bidirectionally control pain circuits in mice using magnetic fields and a fusion protein, showing both excitatory and inhibitory effects on nociceptor activity.

Cellular and Molecular Basis of Leptin Resistance

The paper identifies mTOR activation in POMC neurons as a key mechanism causing leptin resistance in diet-induced obese mice.

Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake

The paper identifies BNC2 neurons in the hypothalamus that acutely suppress food intake by inhibiting AGRP neurons and are regulated by leptin, sensory cues, and nutritional status.

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

This paper develops magnetogenetic tools to bidirectionally regulate specific neuronal circuits in vivo using magnetic fields and shows their efficacy in motor control and Parkinson's models.

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

This study identifies Rheb as a molecular substrate in the nucleus accumbens that enables drugs of abuse to hijack reward circuits and suppress natural reward responses.

A Subcortical Feeding Circuit Linking Interoception to Jaw movement

This paper identifies a subcortical circuit linking interoception to jaw movement through VMHBDNF neurons, showing their role in regulating feeding behavior and consummatory actions.

FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons

This study shows FGF21 reduces ethanol-induced intoxication by activating noradrenergic neurons, improving recovery from ethanol exposure in mice.

Functional Analysis of Distinct Populations of Subthalamic Nucleus Neurons on Parkinson Disease and OCD-like Behaviors in Mice

The paper identifies Gabrr3-expressing neurons in the STN as critical for locomotion and OCD-like behaviors in mice, showing their potential for targeted therapeutic interventions.

A molecularly defined insular cortex --> central amygdala circuit mediates conditioned overconsumption of food.

The paper identifies a circuit between the insular cortex and central amygdala that promotes overconsumption by suppressing satiety signals through nitric oxide synthase-1 neurons.

A Developmental Role for Microglial Presenilin 1 in Memory

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.

A limbic circuit selectively linking active escape to food suppression

This study identifies stress-responsive neurons in the lateral septum that reduce food intake and body weight through hypothalamic pathways.

Encoding of an engram for food location by satiety-promoting Drd2 hippocampal neurons

This study identifies hippocampal D2R neurons that regulate feeding behavior and encode food location memory through a LEC->Hippocampus->Septal circuit.

Control of non-homeostatic feeding in sated mice using associative learning of contextual food cues

This paper develops a context-induced feeding task to study non-homeostatic feeding in mice and identifies brain regions involved in appetitive conditioning.