Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.
Kaja Plucińska, Charlotte R. Wayne, Henry Sanford…·Ekaterina V. Vinogradova
A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.