The paper introduces aaRSID, an engineered pyrrolysyl-tRNA synthetase for proximity labeling, improving upon existing tools by reducing background and enabling multiplexed proteomics.

bioRxiv · Sep 24, 2026 · PreprintBiochemistry

Cell type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling.

Kaja Plucińska, Charlotte R. Wayne, Henry Sanford, Boby Mathew, Nathalie Ropek, Stephanie M. Adaniya, Corey Model, Nicolás Gómez-Banoy, Ksenia Morozova, Xiongwen Cao, Jeffrey M. Friedman, Ken H. Loh, Paul Cohen, Ekaterina V. Vinogradova

A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.

Cell Reports · Jun 1, 2026Peer-reviewedPhysiology✦ In-depth digest

Beta cells are essential drivers of pancreatic ductal adenocarcinoma development

Cathy C. Garcia, Aarthi Venkat, Daniel C. McQuaid, Sherry S. Agabiti, Alexander Tong, Boby Mathew, REBECCA L. CARDONE, Rebecca M. Starble, Christian F. Ruiz, Christy Zheng, Akin Sogunro, Jeremy B. Jacox, Ken H. Loh, Richard Glenn Kibbey, Smita Krishnaswamy, Mandar Deepak Muzumdar

This study shows that beta cells drive pancreatic ductal adenocarcinoma development through endocrine-exocrine signaling, with obesity enhancing this process via CCK+ beta cell adaptation.

Nature Communications · Feb 27, 2026Peer-reviewedCancer Biology