14-3-3 protein interactions

A Context-Aware 14-3-3 Binding Predictor Enabled by Data Augmentation, Multi-Scale Biological Features, and Protein Language Model Embeddings

The paper introduces CAMP-14-3-3, a framework that improves 14-3-3 binding prediction by integrating multi-scale biological features and protein language model embeddings, outperforming existing methods.

Differential induction of 14-3-3 paralogs expression during early and late adipogenesis

The paper examines how different 14-3-3 protein paralogs are expressed during early and late adipogenesis under varying differentiation conditions and identifies their distinct roles.

Insulin stimulation induces dynamic interaction between 14-3-3 and the C-terminal tail domain of Kinesin-2 subunit KIF3B in vitro

This study shows insulin stimulates a dynamic interaction between 14-3-3ε and KIF3B's C-terminal tail, revealing a regulated mechanism for kinesin-2 cargo specificity.

The Arabidopsis 14-3-3 proteins stabilize BRASSINOSTEROID INSENSITIVE1 at the plasma membrane

This study identifies 14-3-3 proteins as stabilizers of BRI1 by antagonizing its ubiquitination, enhancing BR signaling in Arabidopsis.

Structure Model Analysis Of Phosphorylation Dependent Binding And Sequestration Of SARS-COV-2 Encoded Nucleocapsid Protein By Protein 14-3-3

The paper shows phosphorylation of SARS-COV-2 NCp increases binding energy and stability when interacting with 14-3-3 protein.

Development of predictive QSAR models on the phosphopeptide binding affinity against 14-3-3 isoforms

The paper develops predictive QSAR models to determine phosphopeptide binding affinity against 14-3-3 isoforms and identifies hydrophobic residue patterns as key contributors to binding affinity.

T606-phosphorylation deprives the function of Kaiso as a transcription and oncogenic factor

This study shows that AKT1 phosphorylates Kaiso at T606, promoting its cytoplasmic localization and de-repression of CDH1, with reduced phosphorylation linked to gastric cancer progression.