Dajun Deng

This paper investigates the effects of Ttc22 knockout in mice and finds no significant phenotypes in development, fertility, or colon cancer induction.

This study shows that AKT1 phosphorylates Kaiso at T606, promoting its cytoplasmic localization and de-repression of CDH1, with reduced phosphorylation linked to gastric cancer progression.

This study shows that hydroxymethylated P16 alleles are transcriptionally inactive, demonstrated through engineered P16-specific dioxygenase-induced hydroxymethylation and its effects on cell growth and migration.

This study shows that P16 DNA methylation prevents senescence, promotes proliferation, and extends lifespan in human fibroblasts, potentially contributing to cancer development.