T606-phosphorylation deprives the function of Kaiso as a transcription and oncogenic factor
Wei Tian, Hongfan Yuan, Sisi Qin, Wensu Liu, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng
This study shows that AKT1 phosphorylates Kaiso at T606, promoting its cytoplasmic localization and de-repression of CDH1, with reduced phosphorylation linked to gastric cancer progression.
bioRxiv · Mar 23, 2020 · PreprintMolecular Biology