Arjun Ray

This paper identifies phospholipids that regulate lipid transfer through CETP by enabling a novel 'gliding' mechanism, revealing their critical role in lipid movement and providing new therapeutic insights.

This study identifies QKI as a regulator of splicing fidelity during cardiogenesis by interacting with U6 snRNA to enhance splicing at weak 5' splice sites.

The paper develops a tool to analyze water dynamics inside protein cavities using MD simulations, showing its ability to distinguish cavity water from bulk solvent and characterize its dynamic properties.

DIGEST is a web tool that designs MRM transitions for proteomics by predicting peptide fragmentation patterns and selecting optimal ion pairs to improve assay specificity and reduce experimental time.

The paper introduces a graph-wavelet model to predict protein biophysical properties and assess mutational effects by analyzing amino-acid features in protein structures.

This study analyzes Indian genetic variations in the kinome to identify sequence, structural, and pharmacogenomic differences compared to global datasets, highlighting implications for drug safety and adverse reactions.

The paper identifies potential anti-SARS-CoV-2 compounds from Cissampelos pareira L. using connectivity map analysis and in vitro testing, showing high inhibition of viral replication.

CICLOP detects protein inner cavities with high accuracy, providing residue details, cavity dimensions, and physicochemical properties for functional analysis.

AgAnt predicts agonist/antagonist mode of interaction between receptors and ligands to aid in understanding biochemical processes and drug discovery.

This study identifies molecular links between ESR1 modulation and viral inhibition through transcriptome analysis of Cissampelos pareira extract in MCF7 cells.

The paper shows that GroEL/ES buffers entropic traps in protein folding pathways introduced by mutations, which are rescued by the chaperonin, while it can also edit non-native contacts but is not utilized in vivo.

This paper demonstrates that Francisella novicida Cas9 (FnCas9) has high specificity and low off-target editing, enabling precise genome editing in mammalian cells.

This study investigates the atypical domain communication and function of the yeast Hsp110 chaperone Sse1 using biophysical techniques, revealing unique structural changes and substrate binding mechanisms.