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This paper develops a new 3D culture system and digital analysis method to detect malignantly transformed cells in human cell-based therapeutic products, improving upon conventional assays.

The paper quantifies oxygen gradients in the intestine and recreates them ex vivo to study hypoxia's role in epithelial organization.

This paper develops perfusable 3D models of ureteric bud and collecting duct tubules from hiPSCs to study kidney development and enable drug testing and bioprinting.

The paper investigates the mechanical properties of cement lines compared to bone, finding they are stiffer and harder but have different mineral-mechanics relationships due to particle morphology.

LASSO is a sequence-selective biomolecule isolation platform that achieves high efficiency, low off-target effects, and cost-effectiveness for diverse targets.

This study uses snRNAseq to identify cell-specific pro-repair responses induced by an infusible ECM biomaterial after myocardial infarction.

This study examines how physiological response functions (PRFs) vary across individuals and brain regions in fMRI data and shows that allowing spatial and subject-specific variability improves PRF model performance.

This paper introduces PERFECT PCR, a method that improves DNA data storage density and accuracy, achieving 94% of theoretical maximum storage density with significantly lower error rates.

This study shows that endothelial cell stiffness and type influence biomechanically-induced transcellular pore formation in Schlemms canal cells.

This paper develops a composite hydrogel (C-gel) that enables localized in situ gelation and sustained nanocarrier release in the anterior chamber of the eye, showing 90% polymer retention and over a month of sustained release in mice.

This study develops CRISPR/Cas9 RNA lipid nanoparticles to clear HCMV infections, showing high efficacy and broad strain coverage.

This study uses an ex vivo hindlimb culturing platform with dynamic mechanical loading and PNCOL injection to enhance muscle regeneration and reduce inflammation in critical-size TA muscle defects.

This paper demonstrates HiP-CT with EPR for high-resolution imaging of a whole sheep head, enabling near-micron scale visualization of anatomical features without sectioning.

This paper demonstrates the attachment of PEI-coated microbubbles to neutrophils using click chemistry and electrostatic interactions, enabling ultrasound-responsive targeted delivery without compromising cell viability or migration.

The paper introduces two orthogonal RNA-regulated destabilization domains for three-color mRNA imaging in mammalian cells with minimal RNA perturbation.

The paper introduces a hybrid model combining lattice Boltzmann and finite difference methods to efficiently simulate fluid transport in porous media with moving boundaries, showing a fourfold speed improvement.

This study investigates how ultrasound and enzymes affect amyloid microclots, finding that ultrasound alone is more effective than enzymes in disrupting clot structures.

This paper develops a miniaturized flow chamber to assess calcification in biohybrid implants under physiological flow conditions, showing similar calcification in bovine pericardium and no calcification in polycarbonate urethane.

This paper develops a bioprinted hydrogel graft with a mineral gradient to mimic the osteochondral interface, showing structural and mechanical properties similar to native tissue.