Elisha Krieg

Mapping 3D cellular mechanical activity with matrix-embedded DNA force-history probes

This paper introduces DNA-based force-history probes to map 3D cellular mechanical activity over time, enabling visualization of stress patterns in breast cancer spheroids.

Programmable DNA Origami Caps for Site-Selective Functionalization of Microtubule Tips and Lattice Defects

This paper develops DNA origami caps to selectively functionalize microtubule tips and lattice defects, enabling controlled cargo capture and dynamic visualization.

Assembling a true "Olympic Gel" from >16,000 combinatorial DNA rings

This paper creates a true Olympic gel from over 16,000 DNA rings, showing unique mechanical properties and swelling behavior due to entanglements.

LASSO: versatile and selective biomolecule pulldown with combinatorial DNA-crosslinked polymers

LASSO is a sequence-selective biomolecule isolation platform that achieves high efficiency, low off-target effects, and cost-effectiveness for diverse targets.

Programmable viscoelastic hydrogels uncover mechano-sensing timescales and direct cell polarity

This study uses programmable hydrogels to reveal two mechano-sensing timescales in MDCK cells and shows how dynamic mechanical cues influence cell polarity and morphogenesis.

A spring-loaded and leakage-tolerant synthetic gene switch for in-vitro detection of DNA and RNA

This paper introduces a synthetic gene switch that detects DNA and RNA with high sensitivity and zero background, using a TMSD cascade and fluorescent aptamer output.

A smart polymer for sequence-selective binding, pulldown and release of DNA targets

This paper introduces a methanol-responsive polymer (MeRPy) that selectively binds and releases DNA targets, improving NGS library quality by depleting unwanted transcripts.

Rapid and scalable in vitro production of single-stranded DNA

This paper describes a method for producing high-purity single-stranded DNA for various applications.