Discover, rate, and discuss biology preprints.

This study estimates preferred walking speeds by analyzing center of mass work, finding optimal push-off impulses that minimize energy dissipation across different terrains and demographics.

The paper quantifies steroid hormone interactions with PDMS and models how these interactions disrupt dynamic dosing protocols in microfluidic devices.

The paper uses a physics model to show weakened heart contractility increases bacterial invasion risk in cardiac organoids, with mouse experiments confirming a 80% reduction in endocarditis risk with increased contractility.

This study shows that direct M2 macrophage co-culture promotes fibroblast activation regardless of hydrogel stiffness, mediated by IL6 signaling.

This paper develops 3D printed microtissue cassettes for high-throughput proton radiobiological assays, showing consistent RBE values across different assays.

This study evaluates the ability of Vibrio natriegens to produce nicotinamide mononucleotide (NMN) through metabolic engineering, finding that NAMPT from Chitinophaga pinensis yields the highest intracellular NMN concentration.

This study shows that low-intensity vibrations cause nuclear motion and cytoskeletal changes in mesenchymal stem cells, independent of matrix strain, leading to transcriptional activation.

This study shows that residual stresses in human carotid artery layers are not fully released by a radial cut and require layer separation to reveal the stress-free state.

This study analyzes IspH homologs in Bacillus and other bacteria to improve terpenoid production through computational and molecular dynamics methods.

This study develops a composite scaffold combining 3D-printed HA-WOL lattices with chitosan-gelatin cryogels, showing improved mechanical properties and bioactivity for bone tissue engineering.

This study develops a 3D vertex model to analyze multicellular tissue mechanics, revealing strain softening and hysteresis during large deformations.

The paper introduces an open-source model for automatically segmenting osseous structures of the paranasal sinuses, achieving high accuracy in ex vivo CT scans.

This paper introduces a method to accelerate multi-shell diffusion MRI by using Gaussian process reconstruction, improving image quality and enabling faster scans.

This paper develops a digital interface for precise, brain-state-dependent TMS timing, achieving sub-millisecond accuracy in EEG-TMS synchronization.

This study introduces CRISPR-TO to manipulate RNA localization in neurons, showing it affects neurite outgrowth and axonal regeneration.

NeuroSimo provides open-source software for real-time closed-loop EEG-TMS stimulation, enabling flexible and precise control with low timing error.

This paper demonstrates that adeno-associated viruses can be coupled to nanoparticles to deliver them specifically to target tissues, with an example of brain-targeting using AAV serotype CAP-B10.

This paper introduces nonlinear sound-sheet microscopy to image opaque organs at the capillary and cellular scale, achieving faster imaging speed, larger volume, and higher resolution than existing biomolecular ultrasound techniques.

This study demonstrates that ultrafiltration can purify circRNA with 86% purity and 50% yield, outperforming SE-HPLC.