Discover, rate, and discuss biology preprints.

This study introduces SOPHI, a method to map ultra-slow CSF flow in the human brain, revealing coherent flow patterns linked to vascular anatomy and potential CSF efflux pathways.

This study develops a BMSC-laden PEGDA/HAMA hydrogel with distinct stiffness profiles to repair osteochondral defects, showing improved defect filling and subchondral bone remodeling in vivo but limited collagen type II expression.

This study shows that modifying the charge of PET-binding modules can enhance the thermostability and functional persistence of PET hydrolases.

This paper develops BBB-permeable oxazine fluorophores for real-time intraoperative imaging of white matter tracts in neurosurgery.

This study designs compact protein binders targeting BabA, an H. pylori adhesin, using a structure-guided computational pipeline integrating structural, sequence, and evolutionary analyses.

This paper develops a two-stage femtosecond laser fabrication method for PDMS membranes with tunable permeability and mechanical resilience for organ-on-chip applications.

This paper benchmarks signal peptide-mediated protein translocation in Komagataeibacter rhaeticus to enable in situ functionalization of bacterial nanocellulose during biosynthesis.

This paper evaluates a BMP-7 mRNA-lipid nanoparticle therapy for heart failure, showing improved cardiac function and reduced fibrosis in mice, along with suppression of endothelial-to-mesenchymal transition in vitro.

This paper genetically engineers K2P channels to be activated by rapamycin or its analogs, enabling chemogenetic control of cellular membrane potential.

This paper introduces nanoporous polycarbonate as a PDMS-free alternative for oxygen exchange in organ-on-a-chip systems, showing improved oxygen permeability and viability without compromising mechanical robustness.

This paper develops a machine learning framework to optimize phased-array transducers for transcranial focused ultrasound neuromodulation in mice, achieving submillimeter focal precision.

The paper engineers AAV capsids with improved muscle transduction and reduced off-target distribution in non-human primates using the REACH platform.

This paper develops a low-cost fluorogenic peptide biosensor for detecting early enamel demineralization in vitro, showing strong correlation with established QLF measurements.

This paper develops biomineralized SERS nanotags that encode biomolecular identity into machine learning-resolvable plasmonic fingerprints for diagnostic applications.

This paper develops a microneedle patch that sequentially releases three drugs to prevent vein graft restenosis after CABG, showing reduced thrombosis, intimal hyperplasia, and improved graft patency in mice.

This paper develops a liquid-liquid interfacial spinning method to create cell-laden, uniaxially aligned collagen fibres with mechanical properties comparable to tendon collagen and spider silk.

The paper develops cell-permeable C16orf74 peptides that disrupt Calcineurin-NFAT interaction, inhibit T-cell activation, and show minimal cytotoxicity compared to Cyclosporine A.

This study examines the behavioral and circuit-level effects of acute and chronic gastric electrical stimulation in rodents, revealing context-dependent and temporally dynamic changes in anxiety-related behavior and neural activity.

This paper introduces 4D Oxy-wavelet MRI to non-invasively assess mitochondrial function in living brains across the lifespan, validated in mouse models and with human feasibility data.

This paper shows that mechanical stress relaxation in dendritic cells (DCs) influences their functional states, enhancing T cell priming through improved antigen presentation and migration.