Yijen Lin Wu

This study shows that inhibiting MALT1 protease in glioblastoma-associated macrophages reduces immunosuppression and tumor growth by reprogramming macrophages to an M1-like phenotype.

This paper introduces 4D Oxy-wavelet MRI to non-invasively assess mitochondrial function in living brains across the lifespan, validated in mouse models and with human feasibility data.

This paper develops a non-invasive, fast, and gating-free method for longitudinal ECV quantification in rodents using cardiac MRI, validated for myocardial fibrosis evaluation.

This study identifies mitotic block and epigenetic repression as causes of neurodevelopmental defects and neurobehavioral deficits in congenital heart disease using mouse models.

This paper develops a non-invasive DCE-MRI pipeline to model uterine contraction and placental perfusion dynamics in mice, revealing asymmetric placental contractile motion.

This paper characterizes a mouse model of Snyder-Robinson Syndrome with a missense mutation in the Sms gene, revealing behavioral, neuroanatomical, and metabolic defects.

Maternal administration of mitochondrial-targeted JP4-039 mitigates fetal brain injury and preserves mitochondrial function after mid-gestation radiation exposure.

The paper identifies metabolic regulation in left-right patterning using spatial transcriptome data, linking glycolysis and Bmp7 to heart and gut looping.