Kyle H. Vining

This study shows that the viscoelastic properties of an alginate ECM regulate collagen fiber self-assembly through mechanical coupling.

This study shows that matrix stiffness influences epigenomic changes in gingival fibroblasts, with stiff matrices promoting CpG methylation and reduced inflammation, while soft matrices lead to hypomethylation and increased inflammatory signaling.

This paper shows that mechanical stress relaxation in dendritic cells (DCs) influences their functional states, enhancing T cell priming through improved antigen presentation and migration.

This study develops a feeder-free method to generate functional human dendritic cells from pluripotent stem cells, outperforming monocyte-derived dendritic cells in antigen presentation and T cell activation.

The paper uses a multimodal framework to reveal unique mineralization defects in a TBCK syndrome mouse model, identifying early-stage changes in enamel and dentin composition.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

This study models how poroelastic properties of the extracellular matrix affect tumor growth and transport through hydrogel experiments and computational simulations.

This paper develops a gene expression system targeting mineralized tissues using bisphosphonate lipids, demonstrating enhanced RNA delivery and local therapeutic effects in bone regeneration and inflammation.

This study shows that matrix stiffness influences fibroblast-driven immune responses in gingival tissues, with stiff matrices reducing inflammation through non-canonical NFκB and epigenetic pathways.

This study develops a biocompatible polymeric resin for dental adhesion, showing improved bond strength and biocompatibility through triacrylate-trithiol crosslinking.

This study examines mechanical and chemical properties of developing enamel, dentin, and bone in mouse mandibles using multi-modal techniques and finds distinct patterns of changes driven by mineral composition.