Discover, rate, and verify biology preprints.

Prolonged systemic inflammation worsens impairments to astrocyte Ca2+ and functional hyperemia in Alzheimer's disease

This study investigates how prolonged systemic inflammation exacerbates astrocyte dysfunction and neurovascular coupling impairments in Alzheimer's disease.

A Pubic Hair Is 172 Times More Pubic Than a Scalp Hair

This study uses proteomics to distinguish scalp hair from pubic hair, identifying specific keratin-associated proteins and amino acid compositions as markers for anatomical origin.

Technical Note: Focused ultrasound-mediated blood-brain barrier opening for delivery of LNP-packaged modRNA therapy in a mouse model of Niemann-Pick Disease Type C

This study evaluates FUS-BBBO for delivering LNP-packaged modRNA to the cerebellum in NPC mice, finding BBB opening but no detectable protein expression or therapeutic benefit.

Computational modeling of necrosis in neural organoids

This study uses a 3D finite element model to simulate necrosis in neural organoids and evaluates culture methods to reduce necrosis.

ACCURATE PREDICTION OF ASPARAGINE DEAMIDATION IN BIOLOGICS USING ADVANCED MACHINE LEARNING MODELS

This study develops machine learning models to predict asparagine deamidation in proteins, showing improved accuracy over existing methods and reducing development costs.

Rationally Anchored Geometry-Controlled DNA Tetrahedral Nanostructures for Attomolar Impedimetric IL-6 Detection

This paper develops an impedimetric aptasensor using DNA tetrahedral nanostructures for ultrasensitive IL-6 detection with a limit of detection of 55 ag/mL.

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain

This paper develops an engineered membrane translocation domain (MTD4) that enables efficient intracellular delivery of peptides and proteins, demonstrating its effectiveness in vitro and in vivo.

Smartphone-Validated Portable Paper-Based Device Integrated with an Electropolymerized Molecularly Imprinted Polymer for Serotonin Detection in Serum Samples

This paper develops a portable, smartphone-compatible electrochemical sensor for serotonin detection in serum, demonstrating high sensitivity, selectivity, and reliability in clinical samples.

A Selective Multivalent NET-Associated Chromatin Neutralizer Resolves Infection-Associated Inflammation in Severe Sepsis

This paper develops a multivalent NET-neutralizer that reduces inflammation in severe sepsis by targeting DNA-histone chromatin complexes while maintaining antibacterial activity.

Registration-based 3D Light Sheet Fluorescence Microscopy and 2D histology image fusion tool for pathological specimen

LitSHi automatically aligns 3D Light Sheet Fluorescence Microscopy and 2D histology images to improve multimodal tissue analysis.

Oral delivery of mesenchymal stem cell-derived extracellular vesicles to treat intestinal inflammation

This study evaluates oral delivery of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) for treating intestinal inflammation, showing improved stability and therapeutic efficacy with a novel coating formulation.

Evaluating Approaches for Inference Testing of Whole-Brain Densely Sampled Single-Subject Task fMRI Data

This study evaluates statistical methods for analyzing whole-brain task-based fMRI data, finding that a whole-brain voxel-level approach with FDR correction offers highest sensitivity and consistency.

The role of falx cerebri in the selective vulnerability of the splenium in the corpus callosum

This study investigates how the falx cerebri contributes to the splenium's vulnerability in traumatic brain injury using biomechanical simulations.

Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy

This paper develops PPPd-MNs that use PEI's cytotoxicity and Pd catalysis to synergistically treat melanoma, achieving 98% tumor inhibition in mice.

Computational Fluid Particle Dynamics (CFPD)-Based Virtual Next Generation Impactor (vNGI) to Predict the Aerodynamic Particle Size Distribution (APSD) of Respiratory Drug Delivery Products: Toward New Approach Methodologies (NAMs) in Inhaler Performance Evaluation

This paper introduces a virtual NGI (vNGI) model using CFPD to predict APSD of inhaled drugs, validated against experimental data and aligned with NAMs for inhaler evaluation.

Computational Modeling Of Immersed Non-spherical Bodies In Viscous Flows To Study Embolus Hemodynamics Interactions For Large Vessel Occlusion Stroke.

This paper develops a computational model to study embolus-hemodynamics interactions in large vessel occlusion strokes, capturing non-linear dynamics and near-occlusive flow behaviors.

Healthy-to-Stroke Translation of EEG-Based BMIs: EEG Characterization and Reinforcement Learning-Based Decoder Evaluation

This paper evaluates whether population-trained Q-learning Kernel Temporal Difference (Q-KTD) decoders can improve individual stroke decoding through healthy-to-stroke transfer learning.

Unraveling Self-Assembly Mechanisms in Bacterial Cellulose Hydrogels

This study investigates the self-assembly mechanisms of bacterial cellulose hydrogels by analyzing bacterial movement and cellulose secretion dynamics.

High-throughput whole-brain scattering imaging resolves Amyloid plaques through clearing-assisted contrast modulation

This paper introduces CAST, a label-free whole-brain imaging technique that maps amyloid plaques in mouse brains using clearing-assisted scattering tomography.

RNArefine: AI-guided Atomic-Level Refinement of RNA Structures

RNArefine improves RNA structure prediction by refining atomic details and stereochemistry using AI and physics-based methods.