Discover, rate, and discuss biology preprints.

This paper introduces a site-specific mutation model (SSM) for pandemic-scale phylogenetics, showing it better captures mutation patterns in SARS-CoV-2 genomes than classical models.

This paper introduces phyloDE, a method for interspecies differential gene expression analysis that controls FDR and identifies more DE genes with consistent cis-regulatory changes.

This study compares redox responses to heat stress in temperate and tropical Drosophila melanogaster embryos, finding divergent redox shifts that correlate with heat tolerance.

The paper analyzes conditions for the emergence of adaptive polymorphism under long-term evolution, identifying negative trait-dependent selection as a unifying mechanism across ecological, social, and genetic interactions.

The paper shows that annual life-history strategy in seagrass is linked to low-light adaptation through genetic coupling of SAPK7 and CAO genes.

This study shows that a male-expressed mating plug in nematodes increases female fertility by extending reproductive windows and reducing sperm loss, indicating reproductive cooperation rather than male competition.

This study shows that negative autoregulation in gene circuits enables stronger environmental switching by favoring alleles that create strong molecular switches in E. coli.

This study identifies histone-based chromatin regulation components in Asgard archaea, suggesting these features predate eukaryogenesis.

The paper investigates the impact of human activity versus climate change on bee population expansion in Fiji, finding that human occupation, not climate, drove population growth in lowland species.

The paper shows that the clonal raider ant, Ooceraea biroi, occasionally reproduces sexually, generating new genetic combinations and potentially overcoming asexuality costs.

This study uses a digital genomics simulation to show that mutation rates decrease over time due to genetic drift and limited supply of fidelity-improving mutations, while genome size increases as a trade-off.

The paper shows that sublethal immune resistance can mimic tolerance in reaction-norm analysis, challenging the distinction between resistance and tolerance.

The paper tests the Red Queen dynamics hypothesis by analyzing TE distribution and host regulation in 78 teleost fish genomes, finding evidence of coevolutionary arms race.

The paper quantifies amino acid substitution rates in E. coli, finding no significant differences in overall translation error rates among ribosomal variants but unique mistranslation profiles.

This paper introduces engineered balanced lethal systems using CRISPR-based gene drives to sustainably modify wild population densities for suppression or enhancement.

This paper introduces permutation tests to detect evolutionary features from allele frequency timeseries without assuming a model of evolutionary change.

This study conducts whole-genome sequencing of RSV in Bangladesh, characterizing genetic diversity and vaccine targets, and deposits genomes in GISAID.

The paper infers viral proteins acting as public goods during coinfection in bacteriophage MS2 using experimental evolution data and Bayesian inference.

The paper presents an open-access 3D anatomical dataset of extant sharks, providing segmented and annotated models for comparative anatomy and evolutionary studies.

The paper introduces GouMang, a framework to trace karyotype evolution across plants, revealing conserved patterns and the role of whole-genome duplications in adaptation.