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This study identifies organized vulnerability in the aging genome, showing that certain genes and pathways are less mutated while others accumulate more mutations, suggesting a network-based mechanism for cellular decline.

The paper identifies rhabdoviral sequences in alfalfa genomes through bioinformatics analysis, suggesting their integration into the host genome.

The paper uses in vivo single-cell ribosome profiling to study translational changes in mouse epidermal stem cells during aging, finding cell-type-specific translational reprogramming in aged stem cells.

This study identifies eukaryotic retrotransposons that encode prokaryotic-like DNA adenine methyltransferases and shows their adaptation to host 6mA-associated chromatin.

This study examines the long-term temporal stability of 7,288 circulating proteins in older adults over five years, identifying factors like genetic effects and disease stage that influence stability.

The paper identifies autoimmune disease-associated variants that disrupt transcription factor-cofactor complex assembly and enhancer activity using the CASCADE method in Jurkat T cells.

The paper identifies a new bZIP protein motif, BPabZIP, that facilitates nucleosome displacement and binding near nucleosomes in human cells.

The paper compares somatic mutation accumulation in two coral species, finding distinct patterns suggesting different cell lineage development mechanisms.

The paper uses Nanopore sequencing to analyze DENV-2 in Tanzanian mosquitoes, finding a distinct clade related to Asian strains and identifying intra-host variants, suggesting a silent introduction of genotype II.

The paper identifies sex-specific regulatory dynamics in adolescent brain development that may contribute to depression vulnerability through hormone-sensitive gene expression and chromatin accessibility patterns.

This study generates and analyzes year-round aerial eDNA metabarcoding data to improve species detection and monitoring, identifying limitations and best practices for airborne eDNA collection.

The paper identifies H1 histone variants as regulators of transcriptional programs in autism with 16p11.2 deletion, showing their upregulation and link to MAZ.

This paper introduces PfPan, a P. falciparum pangenome that improves structural variant detection and aids malaria control by identifying drug resistance and diagnostic evasion variants.

This study benchmarks local ancestry inference across different genotyping assays and parameters, showing that ultra low-pass WGS with GLIMPSE2 achieves high accuracy, while SNP microarrays perform poorly.

The paper uses single-cell overexpression screens to study how combinations of transcription factors drive gene regulatory networks and cell-type specific gene expression programs.

The paper analyzes genomic data from Brazilian goat breeds to identify runs of homozygosity and assess inbreeding, linking genetic regions to traits under selective pressure.

This study uses genome-wide data to investigate the colonization history and genetic structure of the invasive plant Cotula coronopifolia, revealing multiple lineages, high selfing rates, and the role of dispersal in its spread.

This paper describes a protocol for isolating high-quality genomic DNA and preparing sequencing libraries from wild grape species, overcoming challenges from polyphenols and secondary metabolites.

The paper compares ambient temperature storage methods for parasitic nematode larvae before whole-genome sequencing, finding DESS buffer performs better than FTA cards for individual larvae but comparable results for pooled samples.