Discover, rate, and discuss biology preprints.

This study compares viral replication and host responses in airway epithelial cells to distinguish pathogenic from seasonal coronaviruses, finding HCoV-229E induces severe epithelial injury despite limited replication.

The paper evaluates a rapid Nanopore-based microbiome profiling workflow for women's health outreach at a music festival, demonstrating its feasibility for fieldable citizen science initiatives.

The paper characterizes microbial communities and metabolic potential in northern palsa and peat ecosystems, finding distinct microbial profiles and highlighting hydrogen and carbon monoxide metabolism as key energy sources.

This study determines the atomic structure of mycobacteriophage SWU1 using cryo-EM, revealing key architectural features critical for virion assembly and infection.

This study evaluates the effects of Lactobacillus postbiotic supplementation on intestinal permeability, nutrient digestibility, and gut microbiome/metabolome profiles in aging cats, finding no effect on permeability but improved nutrient digestibility and sequence-dependent microbiome changes.

This study links polyphosphate metabolism genes to hydroxyapatite biomineralization in Methanobacterium AMB_03, showing that polyphosphate synthesis enables carbonate-substituted hydroxyapatite precipitation under phosphate-enriched conditions.

This study shows MmuPV1 and HPV16 E6 oncoproteins disrupt NF-κB signaling by increasing nuclear IKKα localization, suggesting a shared mechanism in papillomavirus persistence.

The paper shows that some bacteria grow better on mixed carbon sources than on individual ones, and links this to their genetic makeup and metabolic preferences.

This study identifies fss genes that regulate stalked cell morphogenesis and cell cycle progression independently of the flagellum in Caulobacter crescentus.

The paper quantifies T6SS prevalence in Gram-negative bacteria using genome analysis and finds it is present in 41% of well-sampled genera.

SPARK quantifies phage-antibiotic interactions using growth curves and shows synergy, antagonism, and dynamic changes across bacterial isolates and time.

The paper identifies a ciliogenesis-primed secretory cell state preferentially infected by seasonal H1N1 IAV in human airway epithelium.

This study examines microbial community dynamics in a photobioreactor using agricultural waste gas streams, showing spatially structured communities and partial nitrogen recovery.

This study shows that reduced swimming motility accompanies B-lactam antibiotic resistance in E. coli through efflux mechanisms, with motility recovery after antibiotic removal.

This study shows engineered DNA materials influence microbial physiology and community dynamics by altering stress responses and shaping genetic interactions in wastewater microbiomes.

This study shows that wild frass enhances BSFL growth on rabbit manure by introducing lignocellulose-degrading microbes, which are lost in captive-reared frass.

This study identifies noncanonical RNA junctions and hidden coding potential in PEDV using integrated transcriptomic and translatomic approaches.

This study investigates the evolutionary distribution of chemosensory systems in Actinomycetota, finding lineage-specific retention and expansion, with TCS playing a dominant role in regulatory networks.

This study investigates the role of Plasmodium falciparum ACS10 in fatty acid acquisition and lipid synthesis during the asexual blood stage, showing its necessity for incorporating specific fatty acids into parasite lipids.