Kanta Subbarao

This study compares viral replication and host responses in airway epithelial cells to distinguish pathogenic from seasonal coronaviruses, finding HCoV-229E induces severe epithelial injury despite limited replication.

The paper analyzes the antigenic evolution of influenza B virus hemagglutinin over 8 decades, identifying epistatic networks that balance antigenic novelty with viral fitness.

This paper develops stable, clamp-free Sarbecovirus spike trimers for vaccine development, showing they elicit high neutralizing antibodies and broad protection in mice.

This study isolates and characterizes contemporary seasonal human coronaviruses, showing differences in cell tropism and growth compared to lab-adapted strains.

This study compares traditional mAb infusion with mRNA/LNP-based de novo mAb expression in mice, finding high serum concentrations but compromised protective capacity due to anti-drug antibodies.