Constitutively-active Positive Transcription Factor b (P-TEFb) prevents viral latency.
Fang Huang, Kenji Nishiura, Koh Fujinaga
The paper shows that expressing a constitutively active CycT1 protein in resting CD4+ T cells delays viral latency.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Fang Huang, Kenji Nishiura, Koh Fujinaga
The paper shows that expressing a constitutively active CycT1 protein in resting CD4+ T cells delays viral latency.
Hongbo Wang, Yao Yu Yeo, Chong Wang…·Bo Zhao
This study uses a genome-wide CRISPR-Cas9 screen to identify host factors essential for EBV B cell infection, revealing new pathways and potential therapeutic targets.
Cameron G. Roberts, Supender Kaur, Shun‐Je Bhark…·Jonathan N. Pruneda
This study identifies a novel E3 ligase secreted by Pseudomonas aeruginosa that regulates virulence through ubiquitin modification.
Nichole A. Ginnan, Carmen Rodriguez, Brian J. Sanderson…·Maggie R. Wagner
The paper examines how climate influences osmotic stress tolerance in Luteibacter populations, finding distinct genomic strategies in semi-arid and humid strains.
Wenting Liu, Rick Gelhausen, Lisa Werland…·Jing Yuan
This study identifies 338 previously unannotated small open reading frames in UPEC strain CFT073, with functional evidence for nine intergenic sORFs and potential roles in stress response.
Avital Akerman-Arad, Aleks Danov, Yuval Chausho…·Asaf Levy
The paper uses an XGBoost classifier to identify novel T6SS effectors in bacterial genomes, validating three new toxins with cytotoxic effects and structural features.
Lisa Werland, Gabriele Malengo, Wenting Liu…·Jing Yuan
The paper shows how two small proteins, SafA and MgrB, work together with magnesium to control the PhoQ/PhoP signaling system in E. coli, enhancing sensitivity to environmental changes.
Cassandra L. Ettinger, Jonathan A. Eisen, Jason Stajich
This study uses deep metagenomic sequencing to recover MAGs from Zostera marina, identifying a novel chytrid in the Lobulomycetales order and other eukaryotic lineages with genomic novelty.
Hildah Amutuhaire, Michael Dubovis, I. V. Plyushchenko…·Eddie J. Cytryn
This study integrates genomic, transcriptomic, and metabolomic analyses to reveal temporally coordinated biosynthetic programs in the rare actinomycete Saccharomonospora xinjiangensis XJ-54 that produce antifungal compounds.
Jeffrey R. Singer, D. Annie Doyle, Dillon E. Kunkle…·Eric Patrick Skaar
This study shows that enterobactin synthesis and uptake are essential for multi-drug resistant Klebsiella pneumoniae to grow under zinc limitation, independent of iron and Zur regulation.
This study identifies two isoforms of NADH-dependent nitrite reductase in extremophiles, revealing distinct expression patterns that may enhance nitrogen assimilation in nutrient-poor environments.
Guy Schleyer, Max Emil Schön, Christian Hertweck, Matthias Fischer
This study investigates how giant virus and virophage co-infection alter the host lipidome, finding distinct lipid remodeling patterns associated with each infection type.
Soojin Yu, Seong-Ryong Yu, Myung Kyung Choi…·Yong‐Sun Bahn
The paper identifies the protein phosphatase 2C domain of adenylyl cyclase in Cryptococcus neoformans as essential for its pathobiological functions, affecting virulence and immune response.
Kirsi Savijoki, Bhawani Chamlagain, Minnamari Edelmann…·Pekka Varmanen
This study shows that carbon source determines metabolic states in Propionibacterium freudenreichii, affecting redox balance and vitamin B12 biosynthesis.
W. Robert Shaw, Philipp Schwabl, Maurice A. Itoe…·Flaminia Catteruccia
The paper shows that additional blood meals increase Plasmodium falciparum sporozoite infectivity to hepatocytes by altering their transcriptional profiles.
Egbert Schwartz, Michaela Hayer, Rebecca L. Mau…·Jennifer Pett-Ridge
This paper introduces internal DNA standards for DNA-qSIP to enable comparison of results across laboratories and support a global database of microbial growth and nutrient assimilation rates.
Thu Ha Nguyen, Dong Ju Lee, Mahmoud Soliman…·Kyoung‐Oh Cho
This paper identifies cereblon (CRBN) as a host factor that promotes influenza virus replication by degrading AMPK, shifting cellular metabolism to support viral growth.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke…·Daniela Zühlke
This study examines the time-resolved transcriptomic and proteomic changes in E. coli after cold atmospheric plasma treatment in an emulated wastewater environment, revealing both immediate damage responses and delayed prophage activation.
Adam Taylor Ruka, Vojtěch Lanta, Samresh Rai…·Klára Řeháková
This study examines microbial community structure in glacier forefields, finding that host identity, time, and habitat heterogeneity shape bacterial and fungal communities across different successional stages.
Barbara Pees, Celia Escudero‐Hernández, Avril Von Hoyningen-Huene…·Katja Dierking
The paper identifies a symbiont-derived biosurfactant that links host neuroimmune control of intestinal peristalsis with bacterial susceptibility to expulsion.